Bladder
The Injectrode aims to redefine how bladder conditions are treated
Understanding Bladder Conditions and Peripheral Nerve System (PNS) Stimulation
Bladder conditions affect a significant portion of adults, primarily women. They are often associated with spinal cord injuries, multiple sclerosis, and spina bifida, and can lead to anxiety, depression, poor sleep, and reduced quality of life.
Various treatment methods are commonly used, including catheters, anticholinergic drugs, botox injections, and neuromodulation techniques like sacral, tibial, and pudendal nerve stimulation.
While effective, catheters have been shown to negatively impact a patient’s quality of life, causing embarrassment and taking several months to get used to.
Anticholinergics are considered highly effective, but come with side effects. These drugs are often chosen as a non-invasive option, but they can create a cycle of negative side effects. Many patients discontinue anticholinergics shortly after starting due to ineffectiveness and burden.
Sacral nerve stimulation is considered the most invasive option, and requires clinical expertise to implant. Sacral nerve stimulation is also associated with high costs, reoperation rates, and complications. Percutaneous tibial nerve stimulation has also been shown to be successful in treating bladder conditions.
Our Approach
Neuronoff is developing solutions for the sacral, pudendal, and posterior tibial nerves using our Injectrode technology. A commonality across all applications is the minimally invasive placement, achievable in under 5 minutes, akin to a standard steroid injection, and necessitating only a steri strip for closure instead of traditional stitches.
You’re beautiful, keep it that way!
Neurostimulation treatments are held back by the invasiveness of currently available procedures
Internal Electronics
Stimulators are implanted inside the body with visible bulging
Patients need to wear dressing to cover externalized lead
Wires Sticking Out
Visible Scarring
Complicated, invasive procedures can lead to visible scarring
Introducing the Injectrode
The answer to chronic pain that both patients and physicians are looking for
Stimulated Externally
Keep all the electronics outside of your body
The Injectrode is deployed entirely below your skin
Nothing Sticking Out
The simple placement procedure is done with an 18ga needle
Minimally Invasive
(smallest in the industry)
Demonstration of the Injectrode System
Injectrode placemened on the pudendal nerve under fluoroscopy
Similar to a mosquito bite!
Example of what the skin looks like after device placement.
shown in a porcine model
We are well on our way!
The Neuronoff team in collaboration with the Shoffstall lab at Case Western Reserve University have received a $500k Ohio 3rd Frontier Grant to study chronic pre-clinical treatments for neurogenic bladder following spinal cord injury.
Secondly, a Department of Defense Spinal Cord Injury Research Program grant was recently submitted to support our upcoming clinical study using the Injectrode to treat neurogenic bladder in individuals with spinal cord injury. This grant submission was a response to an invitation by the DOD specifically for the use of Injectrode technology, demonstrating that federal funding agencies have recognized neuromodulation as a promising treatment option for bladder indications.